There is no difference in the medicinal ingredient contained in ANUSOL™ Multi-Symptom Ointment and ANUSOL™ Multi-Symptom Suppositories. Rely on your clinical experience and the preference of your patient when making your recommendation. Hemorrhoid ointments may work well on both external and internal hemorrhoids, and suppositories may be best for internal hemorrhoids. Always direct your patient to read and follow the label.